Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2-Hydroxyphenylbenzimidazole-based Scaffolds en Route to Donepezil-Like Compounds.

An unsubstituted 2-hydroxyphenylbenzimidazole has recently been included as a scaffold in a series of hybrids (including the hit compound PZ1) based on the framework of the acetylcholinesterase (AChE) inhibitor Donepezil, which is a new promising multi-target ligand in Alzheimer's disease (AD) treatment. Building upon these findings, we have now designed and completed the whole synthesis of PZ1 in the so-called deep eutectic solvents (DESs), which have emerged as an unconventional class of bio-renewable reaction media in green synthesis. Under optimized reaction conditions, the preparation of a series of 2-hydroxyphenylbenzimidazole-based nuclei has also been perfected in DESs, and comparison with other routes which employ toxic and volatile organic solvents (VOCs) provided. The functionalization of the aromatic ring can have implications on some important biological properties of the described derivatives and will be the subject of future studies of structure-activity relationships (SARs).

Uma forma alternativa de combate à escabiose

Trabalho apresentado pelo curso de medicina da Universidade Estadual de Santa Cruz no I Congresso Brasileiro de Extensão Universitária. Fala da elevada incidência de casos de escabiose e cita medidas de intervenção como: capacitação de agentes comunitários de saúde, práticas de educação em saúde incluindo visitas em domicílio e em ambiente escolar... Fala ainda sobre a realização de uma oficina pedagógica para a produção de um medicamento fitoterápico ("Sabão Escabicida"). Documento em PDF. Requer o Adobe Acrobat Reader